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Sunday, August 12, 2012

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How stress and depression can shrink the brain

ScienceDaily (Aug. 12, 2012) ? Major depression or chronic stress can cause the loss of brain volume, a condition that contributes to both emotional and cognitive impairment. Now a team of researchers led by Yale scientists has discovered one reason why this occurs -- a single genetic switch that triggers loss of brain connections in humans and depression in animal models.

The findings, reported in the Aug. 12 issue of the journal Nature Medicine, show that the genetic switch known as a transcription factor represses the expression of several genes that are necessary for the formation of synaptic connections between brain cells, which in turn could contribute to loss of brain mass in the prefrontal cortex.

"We wanted to test the idea that stress causes a loss of brain synapses in humans," said senior author Ronald Duman, the Elizabeth Mears and House Jameson Professor of Psychiatry and professor of neurobiology and of pharmacology. "We show that circuits normally involved in emotion, as well as cognition, are disrupted when this single transcription factor is activated."

The research team analyzed tissue of depressed and non-depressed patients donated from a brain bank and looked for different patterns of gene activation. The brains of patients who had been depressed exhibited lower levels of expression in genes that are required for the function and structure of brain synapses. Lead author and postdoctoral researcher H.J. Kang discovered that at least five of these genes could be regulated by a single transcription factor called GATA1. When the transcription factor was activated, rodents exhibited depressive-like symptoms, suggesting GATA1 plays a role not only in the loss of connections between neurons but also in symptoms of depression.

Duman theorizes that genetic variations in GATA1 may one day help identify people at high risk for major depression or sensitivity to stress.

"We hope that by enhancing synaptic connections, either with novel medications or behavioral therapy, we can develop more effective antidepressant therapies," Duman said.

The study was funded by the National Institutes of Health and the Connecticut Department of Mental Health and Addiction Services.

Other Yale authors of the paper are Bhavya Voleti, Pawel Licznerski, Ashley Lepack, and Mounira Banasr.

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The above story is reprinted from materials provided by Yale University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Hyo Jung Kang, Bhavya Voleti, Tibor Hajszan, Grazyna Rajkowska, Craig A Stockmeier, Pawel Licznerski, Ashley Lepack, Mahesh S Majik, Lak Shin Jeong, Mounira Banasr, Hyeon Son, Ronald S Duman. Decreased expression of synapse-related genes and loss of synapses in major depressive disorder. Nature Medicine, 2012; DOI: 10.1038/nm.2886

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/MD3pp_0x9Ks/120812151659.htm

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Syrian opposition leader calls for no-fly zone

This citizen journalism image provided by Shaam News Network SNN, taken on Saturday, Aug. 11, 2012, purports to show Syrians standing in the rubble of a destroyed building from Syrian forces shelling in Khaldiyeh neighborhood, Homs province, central Syria. (AP Photo/Shaam News Network, SNN)THE ASSOCIATED PRESS IS UNABLE TO INDEPENDENTLY VERIFY THE AUTHENTICITY, CONTENT, LOCATION OR DATE OF THIS CITIZEN JOURNALIST IMAGE

This image made from amateur video released by the Shaam News Network and accessed Sunday, Aug. 12, 2012, purports to show a Syrian man reacting after men, let, lifted a body from the rubble of a destroyed building caused by Syrian forces shelling in Kfarnebel, Idlib province, northern Syria. (AP Photo/Shaam News Network via AP video) THE ASSOCIATED PRESS IS UNABLE TO INDEPENDENTLY VERIFY THE AUTHENTICITY, CONTENT, LOCATION OR DATE OF THIS HANDOUT PHOTO

BEIRUT (AP) ? The head of Syria's main opposition group in exile called Sunday for international powers to impose a no-fly zone in border areas to protect civilians who are coming under increasingly intense attacks by regime warplanes and helicopters.

The president of the Syrian National Council, Abdelbaset Sieda, told The Associated Press that such a move by the international community would show President Bashar Assad's regime that his opponents around the world are serious.

The Syrian opposition has been calling for a no-fly zone over Syria for months. But Sieda renewed the plea a day after U.S. Secretary of State Hillary Rodham Clinton said Washington and Turkey were discussing a range of steps including a no-fly zone over some parts of Syria as the regime increasingly uses its air force to attack rebels.

"There must be special protection," Sieda said by telephone. "The numbers of martyrs are increasing and destruction too. If the country keeps going this way, then we are heading to a catastrophe."

Asked who will impose the no-fly zone, Sieda said: "We leave it to the international community."

Russia and China have vetoed attempts to pass tough U.N. Security Council resolutions aimed at Assad's regime. Last week, the U.N. and Arab League envoy to Syria, Kofi Annan, announced his resignation, following a frustrating six-month effort that failed to achieve even a temporary cease-fire.

Sieda said the no-fly zone should be along borders with Jordan and Turkey, adding that the opposition had called for such a move during last month's Friends of Syria meeting in Paris attended by world powers.

"Now that Syria's air force is taking part in bombing cities and towns, there must be protection for the Syrian people. There must be a no-fly zone so that there will be safe havens to refugees," he said.

Syria's civil war has spread to almost every province in the country and the death toll has increased over the past weeks. Activists say more than 20,000 people have been killed since the revolt against Assad's authoritarian rule began in March 2011.

Activists reported more clashes Sunday in some Damascus suburbs, the battleground city of Aleppo in the north, central Homs province, and the restive southern town of Daraa. The U.K.-based activist group Syrian Observatory for Human Rights said it had no immediate reports of casualties.

The deaths of two Syrian journalists on Saturday were reported on Sunday.

State-run news agency SANA said one of its reporters, Ali Abbas, was killed at his residence in Damascus. The report blamed an "armed terrorist group" ? the regime's catch-all term for its opponents ? but gave no further details.

Pan-Arab satellite news channel Al-Arabiya television said that Bara'a Yusuf al-Bushi, a Syrian national and army defector who worked with the station and several other international news organizations, was killed in a bomb attack while covering a story in al-Tal, a suburb in northern Damascus.

Journalists have suffered a number of casualties in the uprising, and in recent months there have been several attacks on pro-regime media.

The Observatory said that government forces were able to retake the northern town of Ariha, in the restive Idlib province, that had been under rebels control for months. The group said troops backed by tanks entered the town late Saturday and quoted witnesses as saying that many people were detained and some were the victims of "summary executions."

Also Sunday, SANA said troops killed Wael Mohammed al-Majdalawi who is a leader of the Sunni group al-Nusra Front, that claimed responsibility for deadly attacks over the past months including last week's killing of a prominent Syrian television broadcaster, who had been reported missing since July 19.

In a video released Sunday, Capt. Abdul-Nasser Shumeir, who commands the rebel "Baraa Brigades" said government troops launched two attacks in an attempt to free 48 Iranians they have been holding for 10 days. He said Assad's regime is responsible for the safety of the Iranians adding that any negotiations for their release should come after government forces lift the siege imposed on rebel-held areas.

He also called on the Iranian people to pressure their government to stop its support to Assad's regime. Rebels claimed the men are military personnel, including some members of Iran's powerful Revolutionary Guard, who were on a "reconnaissance mission" to help Assad's crackdown. Iran, however, says the group was pilgrims visiting a Shiite shrine in Damascus.

Syrian state news agency SANA also reported that security forces ambushed an armed group in Aleppo and killed and wounded some of them. It said that al-Safira residents in Aleppo prevented gunmen riding in five cars mounted with machine guns from entering their area.

The Observatory said three children, whose ages were between six and 11, were killed Sunday when a bus they were fleeing in with their parents from the Shammas neighborhood of the central city of Homs came under fire. It said government troops were conducting operations in the area.

In Cairo, the Arab League said an emergency meeting of Arab foreign ministers on Syria that had been scheduled for Sunday in Saudi Arabia has been postponed. It did not say why the meeting was postponed or give a new date.

___

Associated Press Writers Jamal Halaby in Amman, Jordan and Michael Casey in Dubai, United Arab Emirates, contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-08-12-Syria/id-ec018f5d35da49d192b46aa8f9737f17

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Saturday, August 11, 2012

Welcome to Hurricane Season | Blogs | ITBusinessEdge.com

Anyone taking a look at the image in this link and those that follow, which appear at weather.com this week, should have a good idea what this post is about: It is time ? perhaps past time ? to get ready for the hurricane season.

It?s an ominous-looking map. (Somehow, ?Tropical Depression Seven? and ?Remnants of Ernesto? sound more threatening than ?Hurricane Gayle? or ?Hurricane Bob.? The former sounds like slasher films, the latter like some friends who are coming over for a barbeque.) IT Business Edge and other sites have great advice on disaster recovery/business continuity steps for preparedness in general and hurricanes in particular.

Here is the best piece of advice, however: Do something. There is a perfect way to do crunches, the breast stroke or to jog. But by just getting on the floor and bending up and down, jumping in the pool and paddling back and forth or putting on sneakers and ambling down the road, you are gaining a large chunk of the benefits that would accrue from doing the activities in a way that Jillian Michaels would approve.

The point is that companies shouldn?t be intimidated by the detailed list of steps to take and things to do. Such an overload of information can lead companies to either not address the issue at all or to over-research and fall victim to ?paralysis by analysis.?

Two pieces of advice that should be taken is to make DR/BC somebody?s job, and make sure that person has a champion in the upper-level hierarchy. Of course, how this manifests itself will be different depending on the precise size and nature of the company.

At the highest level, the idea is to change DR/BC from being a best-effort initiative that is done when somebody has some spare time to being something that is in the job description of a person who will have to show what steps were taken when review time rolls around. It also is important to make sure that the person charged with DR/BC chores has the backing of a C-level executive.

PCMag, in the first of four articles on DR/BC, does a nice job of setting the scene. The first point is that truly addressing this challenge begins long before the incident occurs. The writer walks through some of the things that flow from that: It is important to have mirror versions of mission-critical apps and systems running, and systems and procedures must be in place to carry out necessary tasks even if IT staff are off line or absent. The bottom line:

In short, IT contingency in wake of emergencies should be as seamless, as compliant with corporate security policies, and as easy for end-users to access as possible.

Blaine Raddon, Acronis? the general manager for the Americas, looked specifically at hurricane preparedness in this commentary at Data Center Knowledge. He begins by pointing out that this year?s forecast calls for 11 named storms and six hurricanes ? with two being category three or higher.

Raddon pointed to research Acronis commissioned from the Ponemon Institute. The good news is that many organizations are using virtualized environments, which can be considered the raw ingredient to a good DR/BC platform. Unfortunately, this potential tool is not being cared for properly:

Virtual machines need protecting, too. While 62 percent of U.S. respondents in the 2012 Disaster Recovery Index believe the migration to a virtualized environment will make it easier to ensure that their backup and disaster recovery operations are efficiently managed, an overwhelming 44 percent still don?t back up their virtual machines as often as their physical ones.

Raddon suggests that more companies are turning toward the virtual machine?s cousin, the cloud, for help in DR/BC. The use of the cloud for DR/BC is set to grow, especially because it also brings the huge advantage of cutting opex in day-to-day activities.

If your business has offices in the South or the East Coast, it is likely that storm clouds ? big and dangerous-looking storm clouds ? will threaten some time during the next few months. Those who haven?t paid attention to DR/BC don?t have time to get a full platform up and running. By the same token, it never is too late to start. The first steps are to empower and then to look at implementing DR/BC as seamlessly as possible with ongoing IT functions such as virtualization and the cloud.

Source: http://www.itbusinessedge.com/cm/blogs/weinschenk/welcome-to-hurricane-season/?cs=50950

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PT Marketing Expert Advises Use of Bundled Services for ...

11th August 2012 Cat: Obama News with

Denville, NJ (PRWEB) August 11, 2012

?President Obama?s plan to computerize health care records is a major step forward,? said Chhoda. ?Setting a system in place isn?t that difficult and includes many documentation benefits for physical therapists? he added. To know more about PT documentation functions, check this website, http://physicaltherapydocumentation.com/physical-therapy-documentation/physical-therapy-documentation-and-its-function/.

Chhoda utilizes an array of offices systems to streamline office procedures such as billing, documentation of physical therapy services and appointment scheduling. Several physical therapy EMR systems are on the market, which is why Chhoda advises therapists to conduct due diligence when selecting an EMR to ascertain which one is best for the individual practice.

Making the transition to an EMR opens up enormous possibilities and provides therapists with an array of tools for better patient care, to boost reimbursements and market physical therapy practices more efficiently. Click here to acquire more tips to have a successful clinic.

Chhoda?s office can be reached by phone at 201-535-4475. For more information, visit the website at http://www.emrnews.com.

ABOUT NITIN CHHODA

Nitin Chhoda PT, DPT is a licensed physical therapist, a certified strength and conditioning specialist and an entrepreneur. He is the author of ?Physical Therapy Marketing For The New Economy? and ?Marketing for Physical Therapy Clinics? and is a prolific speaker, writer and creator of products and systems to streamline medical billing and coding, electronic medical records, health care practice management and marketing to increase referrals. He has been featured in numerous industry magazines, major radio and broadcast media, and is the founder of Referral Ignition training systems and the annual Private Practice Summit. Chhoda speaks extensively throughout the U.S., Canada and Asia. He is also the creator of the Therapy Newsletter and Clinical Contact, both web-based services to help private practices improve communication with patients, delivery better quality of care and boost patient retention.

Find More President Obama Press Releases

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Personal Development Guidance That Will Help You Be Successful

Free Article Marketing | Personal Development Guidance That Will Help You Be Successful

Personal Development Guidance That Will Help You Be Successful

By:

If you're reading this, then you're most likely considering self improvement Self improvement can help you ghds boost on your own on every stage, and might basically alter your lifestyle in a number of various ways. This short article will offer you some great tips that will assist you on your quest in the direction of self-enhancement.

Attempt to conserve a positive prospect. An upbeat frame of mind can perform miracles for your personal frame of mind. Consciously consider your toughest to not permit your self get too stressed, concerned, or discouraged - regardless of what the problem. Just informing yourself that issues will probably be okay can occasionally help you stay sensing upbeat for long enough to succeed to make that accurate.

In relation to self improvement you ought to be certain that you are currently being the ideal you may to your self. This is very important since should you not give yourself a break effectively and if you lie to on your own then you certainly will in no way expand to get the full person who you possibly may possibly grow into.

Prior to reacting to your struggle, remember to feel. Even if it is only 30 secs of your energy, these mere seconds will provide your mind time and energy to method ghds information and facts that your particular first gut response might have neglected. Don't make this pondering time into the reason for to never taking measures, by the way. Established a timeline time when a choice has to be made.

Have someone you care about you can trust on be your confidant. As you go via your trip of self improvement you will need someone to inflatable bounce your feelings and sensing off of. It is very good to experience a visit particular person you are aware will probably be genuine along and may explain to it want it is.

When a person does one thing remarkable or displays development, call them on it! Society can make it increasingly challenging to identify everybody with regard to their development and abilities. When your waiter or cashier was helpful and attentive, make a particular ghds hard work to phone the business and pass on that info to their supervisor. Getting acknowledgement, for the smallest stuff, has the ability to fully make someone's day.

Do not quit. You will have to strive to accomplish what you want, nevertheless the final result makes it worth while. Take a look at individuals close to you, and ask oneself where they could be today when they got not cease, or got quit in certain cases. Find the right examples to go by.

Self-help is focused on tracking your day to day actions. An useful tip for trying to better yourself is: try to examine a scenario from various perspectives instead of centering on one personal cheap ghd straghteners viewpoint. Reading other peoples' motives offers knowledge to your personal in regions you might not have well before.

Personal development can be something that could advantage absolutely everyone, no matter who they are. Placing true time and effort into boosting on your own could make you more content and more pleased with ghds existence. This information has given you excellent suggestions that can help you achieve success inside your self improvement attempts. Everything is up to you.

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Friday, August 10, 2012

Beautiful, Expensive Stereo Gear That Hits the High End of Hi-Fi

If you've got a few hundred grand burning a hole in your Prada slacks, a high-end audio show is the place for you.

Source: http://feedproxy.google.com/~r/GearFactor/~3/r9dyqwg8-lY/

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